N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide

Name	EPZ015666
Synonyms	EPZ015666 GSK3235025 EPZ-015666 EPZ 015666 GSK-3235025 GSK3235025 (EPZ015666) (S)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
CAS	1616391-65-1

Molecular Formula	C20H25N5O3
Molar Mass	383.44
Density	1.331±0.06 g/cm3(Predicted)
Melting Point	124-131°C
Boling Point	686.4±55.0 °C(Predicted)
Solubility	DMSO
Appearance	powder
Color	white to beige
pKa	12.40±0.46(Predicted)
Storage Condition	2-8°C
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
In vitro study	EPZ015666 shows ovarian cellular activity that blocks symmetric dimethylation of SmD3 and inhibit propagation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1) with IC50 of 96-904 nM. EPZ015666(GSK3235025) exhibited potent cellular activity, blocking symmetric dimethylation of SmD3, and inhibiting proliferation of MCL cell lines (Z-138, Granta-519, Maver-1, Mino, and Jeko-1), the IC50 was 96-904 nM.
In vivo study	EPZ015666 (200 mg/kg, p.o.) displays robust anti-tumor activity in MCL Xeno raft animal models. EPZ015666 (200 mg/kg, p.o.) strong anti-tumor activity was demonstrated in the MCL xenograft animal model.

Last Update：2024-01-02 23:10:35

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Product Name: EPZ-015666 Request for quotation
CAS: 1616391-65-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

Product Name: EPZ015666 Visit Supplier Webpage Request for quotation
CAS: 1616391-65-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide Request for Quotation